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Index > Protein center > Aif1(Gene name) > Mouse
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  • Aif1 (Gene name),
  • Allograft inflammatory factor 1 (Protein name ),  AIF1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Aif1(Iba1);
    Protein name:
    Allograft inflammatory factor 1(AIF-1);
    Alternative:
    Ionized calcium-binding adapter molecule 1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer (Potential). Monomer. Interacts with LCP1.
    Function:
    Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
    Subcellular Location:
    Cytoplasm cytoskeleton Cell projection ruffle membrane Peripheral membrane protein Cytoplasmic side Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.
    Protein Attributes:
    Sequence length:
    147
    Sequence:
    50:
    MSQSRDLQGG | KAFGLLKAQQ | EERLEGINKQ | FLDDPKYSND | EDLPSKLEAF | 
    100:
    KVKYMEFDLN | GNGDIDIMSL | KRMLEKLGVP | KTHLELKRLI | REVSSGSEET | 
    147:
    FSYSDFLRMM | LGKRSAILRM | ILMYEEKNKE | HKRPTGPPAK | KAISELP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse AIF-1
    Cat.:
    E1251h
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    Packing:
    96T
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    ELISA Kit for Mouse AIF-1
    Cat.:
    E1251m
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    96T
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    ELISA Kit for Mouse AIF-1
    Cat.:
    E1251r
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    MSDS:
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    96T
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    ELISA Kit for Mouse AIF-1
    Cat.:
    E1251b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse AIF-1
    Cat.:
    E1251p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse AIF-1
    Cat.:
    U1251h
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse AIF-1
    Cat.:
    U1251r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse AIF-1
    Cat.:
    U1251b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse AIF-1
    Cat.:
    U1251p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse AIF-1
    Cat.:
    U1251m
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse AIF-1
    Polyclonal Antibody for Mouse AIF-1
    Cat.:
    P1251Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse AIF-1
    Polyclonal Antibody for Mouse AIF-1
    Cat.:
    P1251Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse AIF-1
    Cat.:
    P1251Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse AIF-1
    Monoclonal Antibody for Mouse AIF-1
    Monoclonal Antibody for Mouse AIF-1
    Monoclonal Antibody for Mouse AIF-1
    Monoclonal Antibody for Mouse AIF-1
    Protein for Mouse AIF-1
    Protein for Mouse AIF-1
    Protein for Mouse AIF-1
    Protein for Mouse AIF-1
    Protein for Mouse AIF-1

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    Linearity
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    References
    1. 1.
      "Allograft inflammatory factor-1 augments productions of interleukin-6, -10, -12 by a mouse macrophage line."
      Watano K. , Iwabuchi K. , Fujii S. , Ishimori N. , Mitsuhashi S. , Ato M. , Kitabatake A. , Onoe K.
      Immunology104:307-316(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
    2. 2.
      "Structure of the mouse iba1 gene."
      Imai Y. , Ohsawa K. , Kohsaka S.
      Submitted (2000-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
      strain: 129/SvJ.
    3. 3.
      "Allograft inflammatory factor-1 gene."
      Hu S.P. , Russell M.E.
      Submitted (1996-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
      strain: 129/Sv.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Testis.
    5. 5.
      "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T. , Rowen L. , Aguado B. , Ahearn M.E. , Madan A. , Qin S. , Campbell R.D. , Hood L.
      Genome Res.13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: 129.
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Mammary tumor.
    7. 7.
      "Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia."
      Ohsawa K. , Imai Y. , Kanazawa H. , Sasaki Y. , Kohsaka S.
      J. Cell Sci.113:3073-3084(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    8. 8.
      "Iba1 is an actin-cross-linking protein in macrophages/microglia."
      Sasaki Y. , Ohsawa K. , Kanazawa H. , Kohsaka S. , Imai Y.
      Biochem. Biophys. Res. Commun.286:292-297(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "Macrophage/microglia-specific protein Iba1 enhances membrane ruffling and Rac activation via phospholipase C-gamma -dependent pathway."
      Kanazawa H. , Ohsawa K. , Sasaki Y. , Kohsaka S. , Imai Y.
      J. Biol. Chem.277:20026-20032(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity."
      Ohsawa K. , Imai Y. , Sasaki Y. , Kohsaka S.
      J. Neurochem.88:844-856(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH LCP1
    11. 11.
      "X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding."
      Yamada M. , Ohsawa K. , Imai Y. , Kohsaka S. , Kamitori S.
      J. Mol. Biol.364:449-457(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEX WITH CALCIUM IONS;CALCIUM-BINDING;SUBUNIT
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